A. N. Kolborg ,
 Technical University of Denmark, Lyngby, Denmark
This project makes a first attempt at modelling fluid flow over shark skin on a microscopic level. The modeled fluid flow shows good agreement with theory. Further refinement of the model parameters holds promises of better understanding of this complex fluid flow phenomenon. The COMSOL Multiphysics® model was evaluated against micro particle image velocimetry measurements of the same flow ...
Modeling Arterial Drug Transport From Drug-eluting Stents: Effect of Blood Flow on the Concentration Distribution Close to the Endothelial Surface
F. Bozsak, J.-M. Chomaz, and A. I. Barakat
LadHyX, Ecole Polytechnique
Drug-eluting stents (DES) are commonly used for treating coronary atherosclerosis. Despite the broad effectiveness of DES, ~5% of treated patients experience complications including in-stent restenosis and late-stent thrombosis. Furthermore, drugs used in DES not only inhibit proliferation of smooth muscle cells but also affect re-endothelialization. We have developed a computational model ...
Simulation of Chemotractant Gradients in Microfluidic Channels to Study Cell Migration Mechanism in Silico
P. Wallin, E. Bernson, J. Gold
Chalmers University of Technology, Applied Physics, Biological Physics, Gothenburg, Sweden
Cell migration of endothelial cells along gradients is an important process in vivo and an interesting target for cancer therapeutics. Microfluidics offer very powerful tools to study such migration processes in detail in the lab. In this study, we describe a model to simulate molecular gradients in a diffusion based microfluidic gradient generator and how a cell senses these gradients via cell ...
A Study on Nutrient Mass Transport through Porous Channeled Flat Sheet Membrane and Prediction of Maximum Scaffold Thickness for Viable Cell Culture (In-vitro) by 3D Modeling for Tissue Engineering Application
N. M. S. Bettahalli, B. J. Papenburg , D. S. Stamatialis , M. Wessling 
University of Twente, Enschede, The Netherlands & BMS College of Engineering, Bangalore, India
University of Twente, Enschede, The Netherlands
RWTH Aachen University
Tissue engineering (TE) is a multidisciplinary field involving principles of engineering and life sciences to improve the health and quality of life by repairing, restoring, maintaining, or enhancing tissue and organ function using cells, scaffolds, and growth factors alone or in combination. There are several artificial tissues that are already being used which include fabricated skin, ...
I.M. Abdel-Motaleb, J. Lavrencik 
Department of Electrical Engineering, Northern Illinois University, DeKalb, IL, USA
There is urgent need to monitor dental and oral diseases, such as tooth decay, gum diseases, and teeth grinding. Such monitoring can be achieved by embedding sensors in the mouth. This technique faces some difficulties. The first is how the power needed for the operation of the sensors and the associated electronic chips can be generated. This power can be generated using the pressure exerted by ...
R. Sikorski, B. Chapman, T. Merrill
Rowan University, Glassboro, NJ, USA
A CFD cardiac catheter model was developed to determine the potential for blood hemolysis during administration of local therapeutic hypothermia using a CoolGuide catheter. In vivo animal studies have shown that mild hypothermia may reduce reperfusion injury often associated with heart attack. The CoolGuide Catheter System (CCS) delivers rapid local cooling through a cardiac catheter, reducing ...
J.Borana, J.M.Lee, B.G.Chung
Indian Institute of Technology Guwahati, Guwahati, India
Department of Mechanical Engineering, Sogang University, Seoul, Korea
We developed the dual-micropillar-based microfluidic platform to control cellular behavior. The 4×4 dual micro-pillar based platform consists of 16 circular-shaped outer micropillars and 8 saddle shaped inner-micropillars. We simulated various shapes of inner micropillars to analyze the shear stress inside the inner micropillar. Therefore, this dual-micropillar-based microfluidic platform could ...
A Multiphase Porous Medium Transport Model with Distributed Sublimation Front to Simulate Vacuum Freeze Drying
A. Warning, J. M. R. Arquiza, A. K. Datta
Cornell University, Ithaca, NY, USA
A continuum, porous medium formulation with non-equilibrium sublimation was developed and validated for freeze drying without and with uniform microwave volumetric heating. The model incorporates the effect of Knudsen flow at low pressure and low permeability freeze drying. The distributed, non-equilibrium sublimation demonstrated that the sublimation front is a sharp boundary for high ice ...
N. M. Sundaram, M. Alagappan
PSG College of Technology Coimbatore, Tamil Nadu, India
Cholesterol is an essential lipid for human body. The desired total plasma cholesterol for an individual is less than 5.2 mM (200 mg/dL) and it poses a potential health threat when the level is greater than 6.2 mM (240 mg/dL) . Excessive plasma cholesterol causes poor cardiovascular conditions. The experimental fabrication of nano structured biosensor with advanced materials is more expensive ...
Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA
We are developing approximations of electrically anisotropic materials for use in novel imaging methods. Our modeling work in COMSOL comprises comparisons of anisotropic and layered models in terms of electrical conductivities measured using different strategies. We tested solution stability in one anisotropic case by varying mesh anisotropy. In our case, good approximations to the true ...