See How Multiphysics Simulation Is Used in Research and Development

Engineers, researchers, and scientists across industries use multiphysics simulation to research and develop innovative product designs and processes. Find inspiration in technical papers and presentations they have presented at the COMSOL Conference. Browse the selection below or use the Quick Search tool to find a specific presentation or filter by application area.


View the COMSOL Conference 2023 Collection

Bioscience and Bioengineeringx

Investigation Of Bone Marrow Stem Cells In The Bone Marrow Niche In An In Vitro System

P. Lezuo, M. Stoddart, and M. Alini
AO Research Institute, Davos, Grison, Switzerland

We aim to develop an in vitro culture system to mimic the human bone marrow stem cell niche in an artificial perfusion bioreactor environment to culture human adult stem cells. State of the art human bone marrow stem cell research shows that even smallest changes in the physical, thermo ... Read More

Modeling Bacterial Transport and Removal in a Constructed Wetland System

E. Engström, B. Balfors, and R. Thunvik
Royal Institute of Technology, Stockholm, Sweden

In this study we evaluate transport, retention and subsistence of Escherichia coli (E. coli), a common fecal indicator bacteria, in a model (2x1m) of a constructed wetland. Transport occurs in the unsaturated and saturated zone. Inactivation is accounted for as a kinetic first-order ... Read More

Dynamic Simulation Of Particle Self-Assembly Applied To Microarray Technology

V. Di Virgilio, A. Coll, S. Bermejo, and L. Castañer
Universitat Politecnica de Catalunya, Barcelona, Spain

In this work we want to explore some techniques, microfluidic and electrospray-ionization based, suitable for dynamic microarrays\' fabrication. The fabrication techniques are based on manipulation and self-assembly of selective coated micro and nanobeads. The simulation will include ... Read More

Computer Simulation Of Haematopoietic Stem Cells Migration Using COMSOL Multiphysics

G. Bencheva
Institute for information and communication technologies, Bulgarian Academy of Sciences, Sofia, Bulgaria

Various haematological diseases, including leukaemia, are characterized by abnormal production of particular blood cells. Two important properties of haematopoietic stem cells (HSCs) are used in their therapy, namely: a) rapid migratory activity and ability to \'\'home\'\' to their niche ... Read More

Finite Element Analysis Of Permeation Tests On Articular Cartilage Under Different Testing Conditions Using COMSOL Multiphysics

G. Spatafora[1], and F. Boschetti[1][2]
[1]Structural Engineering Department, Politecnico di Milano, Milan, Italy
[2]IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

Articular cartilage is composed by a charged solid matrix (proteoglycan and collagen fibres) and an interstitial fluid phase. The permeability of articular cartilage is a function of compression load applied on the tissue, the solid matrix underwent a compaction that decreased its value ... Read More

Energy Harvesting from Variation in Blood Pressure through Deformation of Arterial Wall using Electro-magneto-hydrodynamics

A. Pfenniger[1], V.M. Koch[2], A. Stahel[2], and R. Vogel[1]
[1]ARTORG Cardiovascular Engineering, University of Bern, Bern, Switzerland
[2]Bern University of Applied Sciences, Engineering and Information Technology, Biel, Switzerland

The present project aims at modelling a generator that harvests energy from the variation in blood pressure by exploiting the motion of the arterial wall between the diastolic and systolic phase of the cardiac cycle. The concept is to use a highly electrically conductive fluid, which is ... Read More

Analysis Of Particle Trajectories For Magnetic Drug Targeting

A. Heidsieck, and B. Gleich
Zentralinstitut für Medizintechnik, TU München, München, Germany

The technique of magnetic drug targeting binds genetic material or drugs to superparamagnetic nanoparticles and accumulates them via an external magnetic field in a target region. However, it is still a challenge for this approach to succeed in areas with high flow rates, like the aorta ... Read More

Shear Induced Detachment Of Microorganisms Attached To A Plane Wall

B. Boulbène, J. Morchain, and P. Schmitz
Université de Toulouse, NSA, UPS, INP, LISBP, Toulouse, France

We present numerical results involving microorganisms adhering to a plane surface submitted to a shear flow. The purpose is to have a better understanding of the removal mechanisms occurring during the cleaning in place of food processing equipments. The biological cell, i.e. the ... Read More

Finite Element Simulation of Shear Wave Propagation Induced by a VCTE Probe

S. Audière[1,2], M. Charbit[1], E. Angelini[2], V. Miette[2], J. Oudry[2], and L. Sandrin[2]
[1]Institut Telecom, Telecom ParisTech, Paris, France
[2]Echosens, Paris, France

The Fibroscan® (Echosens, Paris, France) device based on vibration–controlled transient elastography (VCTE) is used to non– invasively assess liver stiffness correlated to the hepatic fibrosis. Stiffness is quantified by measuring the velocity of a low–frequency shear wave traveling ... Read More

Laser Interstitial Thermo Therapy (LITT) for Prostate Cancer Animal Model: Numerical Simulation of Temperature and Damage Distribution

M.F. Marqa, P. Colin, P. Nevoux, S. Mordon, and N. Betrouni
University of Lille, CHRU, Lille, France

Laser interstitial thermotherapy (LITT) is a cancer treatment technique in which laser fibers are introduced inside the tumor. While it destroys deep tumors, the LITT procedure allows minimizing the impact on adjacent healthy structures. One of the effective methods to perform treatment ... Read More